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Oxandrolone, was a popular anabolic androgenic steroid brought to the market by Cyril laboratories in 1964 under the trade name anavar. The steroid was first described by Dr. James Wright, a professor at Boston University, who published a paper in the Journal of Clinical Endocrinology and Metabolism in 1967. (1) It was an anabolic steroid with a very slow onset of action and was the first to promote muscular hypertrophy in the human male. It was also a significant component of anabolic steroids such as growth hormone and testosterone enanthate. (1) Testosterone enanthate, a steroid which was introduced in the 1970s by pharmaceutical giant Abbott Laboratories, was an anabolic steroid with slow onset and a fast-acting inhibition of aromatization. (1) It was first tested in men in 1970 and later for women. (2)The effects of testosterone enanthate appeared as positive, muscle growth and fat loss. However, the effects of other anabolic steroids were also reported. (1) The primary anabolic, growth hormone, appeared to have minimal effects, whereas the steroid ephedrine, which is a stimulant, had an effect on the muscle mass and fat loss. (1)A number of studies have investigated the effects of testosterone enanthate and ephedrine. A review published in the Archives of Internal Medicine found that ephedrine and testosterone increased levels of growth hormone and the body weight of male rabbits. (3) A study conducted in the 1960s found that testosterone increased circulating testosterone levels and improved plasma phosphodiesterase concentrations. (4) Other studies have provided no evidence of growth-promoting effects. (2,) (5) An experimental study conducted in 1988 concluded that the use of ephedrine caused significant muscle loss in male rabbits. (6). Another study by Dr. William Banting of the Department of Pediatrics at the Veterans Administration Hospital in Philadelphia, PA, found that ephedrine decreased circulating testosterone in young, physically active males. (7)The effects of ephedrine appeared to be due to an increase in the hypothalamic-pituitary-gonadal axis. (7) The increase was due to a decrease in estrogen levels due to a decrease in the expression of aromatase. (15) The mechanisms for its action are unknown.Some of the recent studies of ephedrine and testosterone include a study entitled "Determination of Sex Hormone Production and Inhibitor (S)-Synthine in the Rat, using a Positron Emission Tomography". (8) An increase in testosterone was foundRelated Article: